: The episode marks the official end of an era as Derek Shepherd and Addison Montgomery finalize their divorce. However, the closure is short-lived; Addison confesses to the full extent of her past relationship with Mark Sloan, leading Derek to declare he never wants to see her again.

Originally aired on October 19, 2006, this episode serves as a major turning point for several central characters as they navigate the messy aftermath of their romantic and professional choices. Episode Overview: " Oh, the Guilt "

A man suffers a heart attack after becoming physically "stuck" to his ex-wife due to a precarious piercing, a case that serves as a literal metaphor for being unable to let go.