Who Classification Of Skin Tumours 〈PC〉

: This term is now used for "intermediate" lesions that exhibit borderline biological behavior but have specific molecular signatures (e.g., BAP1 inactivation or WNT pathway alterations).

: A dedicated new section covers epithelial tumours derived specifically from the nail bed.

: The classification reaffirms the 9-pathway model for melanoma, which classifies lesions based on sun exposure (UV damage), anatomical site (e.g., acral, mucosal), and specific molecular drivers. WHO Classification of Skin Tumours

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: The term "variant" is now reserved strictly for genetic alterations in DNA sequences, rather than being used to describe morphological subtypes. : This term is now used for "intermediate"

: Significant updates were made to dendritic cell and histiocytic neoplasms, as well as T-cell and NK-cell disorders.

: Progress in identifying gene fusions (e.g., YAP1::MAML2 in poromas) has enhanced diagnostic accuracy for sweat gland and hair follicle tumours. This is for informational purposes only

: Each tumour entry includes clear "essential" diagnostic features and "desirable" criteria to improve diagnostic reliability worldwide. Major Clinical Updates by Category 1. Melanocytic Neoplasms