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"We didn't have a choice," Dean snapped, though the conviction was hollow.
In the quiet of a darkened hallway, Dean looked down at the baby. He felt a pull, a strange, magnetic tether he couldn't explain. He moved the infant’s blanket aside, and his heart stopped. There, on the baby's tiny shoulder, was the mark. The Mark of Cain. [S11E1] Out of the Darkness, Into the Fire
If you want to explore more about this specific era of the show: The psychological bond between Sam’s secret struggle with the Rabid infection Castiel’s torture at the hands of the angels "We didn't have a choice," Dean snapped, though
Tell me which character's perspective you'd like to dive into next. He moved the infant’s blanket aside, and his heart stopped
Sam didn't answer immediately. He was staring at the road ahead, where the asphalt seemed to shimmer with heat that shouldn't be there. "We let it out, Dean. We actually let it out."
The first body they found was slumped against a road sign. Then another near a rusted-out truck. These weren't demonic kills or angel smitings. The victims were covered in black, veiny growths, their eyes wide and vacant, as if their very souls had been vacuumed out.