The Virtuous Galleria mellonella Model for Scientific ... - PMC
: It allows researchers to follow the "3Rs" principle (Replacement, Reduction, and Refinement) by replacing vertebrate animals in early-stage studies. Gtlela
: Because these larvae were historically sold as reptile food, recent research focuses on standardizing laboratory breeding to ensure reproducible results across different global labs. The Virtuous Galleria mellonella Model for Scientific
: Despite being an insect, its innate immune system shows remarkable similarities to that of mammals, including specialized cells (hemocytes) that function like human neutrophils. : Despite being an insect, its innate immune
: Unlike many other invertebrates, these larvae can survive at 37°C , which is the human body temperature, making them ideal for studying human pathogens like Candida albicans or Staphylococcus aureus .
: Newer papers highlight its excellence in studying fungal infections and evaluating the effectiveness of new antifungal drug candidates.