A central mechanic involves "Nekro," a powerful narcotic that players can use to enter a drug-fueled rampage. Health management is tied to this addiction; players must use a needle to extract Nekro from the twitching bodies of fallen enemies to refill their syringes.

The game’s narrative focuses on the struggle against corruption and systemic oppression.

Players control a group of outcasts who have been experimented on and must fight for survival in a bleak, decadent landscape.

Players can punch, kick, and use various weapons while navigating through gritty environments like ghettos, prisons, and grim laboratories.