A common cause of freezing is how the game handles internal threading.
Try running the game in Windowed Mode or use a "Borderless Window" tool if the game crashes when Alt-Tabbing or during cinematic-to-dialogue transitions. Known Game Glitches Left dialogue crashes - Deus Ex: Human Revolution
Modern CPUs with many cores can cause the game to fail immediately or during heavy processing tasks. Deus ex human revolution dialogue crash fix
Conflicts between the game's renderer and modern display settings can lead to "soft locks" during dialogue:
Download the Startup Crash Fix from Nexus Mods to patch the executable for modern processors. A common cause of freezing is how the
Alternatively, use Process Lasso to restrict the game to fewer cores (e.g., 4 or 8) to prevent engine overflows.
If the game crashes on launch or during scene transitions, try unticking DirectX 11 in the game's launcher settings. Conflicts between the game's renderer and modern display
Change Anti-Aliasing from MSAA to FXAA ; some users report MSAA causing freezes during intro meetings.