Atopy typically follows a predictable chronological progression:
: Systemic immune priming eventually leads to upper and lower airway inflammation. 3. Key Management Strategies caused by skin barrier defects (e.g.
: Upon re-exposure, allergens cross-link IgE on the surface of mast cells, causing degranulation and the release of inflammatory mediators like histamine and leukotrienes. 2. The Atopic March caused by skin barrier defects (e.g.
: Often the first sign in infancy, caused by skin barrier defects (e.g., filaggrin mutations) that allow for epicutaneous allergen sensitization. caused by skin barrier defects (e.g.